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Precautions

Do NOT use Zestoretic if:

• you are allergic to any ingredient in Zestoretic or another sulfonamide medicine (eg, sulfamethoxazole, glyburide, probenecid)
• you possess a good reputation for angioedema (swelling in the face, lips, throat, or tongue)
• you have a very good kidney artery narrowing
• you are unable to urinate
• you consider dofetilide or ketanserin
• you happen to be pregnant.

Contact a medical expert or physician right away if some of these apply to you.

Some medical ailments may interact with Zestoretic. Tell your doctor or pharmacist when you have any health conditions, particularly if any from the following connect with you:

• if you might be pregnant, likely to become pregnant, or are breast-feeding
• if you take any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• for those who have allergies to medicines, foods, or other substances
• if you happen to be able to become pregnant
• for those who have impaired liver function, blood vessel problems (eg, stroke), cardiovascular disease (eg, congestive heart failure), or high cholesterol
• in the event you possess a good reputation for kidney artery narrowing or decreased kidney function, you are on dialysis, or you've got had a kidney transplant
• for those who have gout, diabetes, or electrolyte imbalances (eg, high or low potassium levels, low blood sodium levels), or you might be over a sodium-restricted diet
• in the event you possess a collagen vascular disorder (eg, lupus, scleroderma), bone marrow problems, or severe disease fighting capability problems
• should you have a very history of allergies or asthma
• if you happen to be scheduled to have major surgery or receive anesthesia.

Some medicines may connect to Zestoretic. Tell your doctor in case you are taking some other medicines, especially any of the following:

• Aldosterone blockers (eg, eplerenone), corticosteroids (eg, prednisone), digoxin, dofetilide, ketanserin, lithium, loop diuretics (eg, furosemide), potassium preparations, potassium-sparing diuretics (eg, triameterene), or trimethoprim because the likelihood of electrolyte problems and irregular heartbeat could be increased
• Barbiturates (eg, phenobarbital), dextran sulfate, diazoxide, or narcotic pain medicine (eg, codeine) as the probability of low hypertension may be increased
• Gold-containing medicines (eg, sodium aurothiomalate) because flushing, nausea, vomiting, and low blood pressure levels may occur
• Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, indomethacin, celecoxib) or salicylates (eg, aspirin) simply because they may decrease Zestoretic's effectiveness
• Insulin, sulfonylureas (eg, glyburide), or other medicines for diabetes (eg, metformin) as their effectiveness may be decreased by Zestoretic.

This is probably not an entire listing of all interactions which could occur. Ask your doctor if Zestoretic may connect to other medicines that you are taking. Check with your health care provider before you begin, stop, or affect the dose from a medicine.

Important safety information:

• Zestoretic may cause dizziness, lightheadedness, or fainting. These effects could possibly be worse if you adopt it with alcohol or certain medicines. Use Zestoretic with caution. Do not drive or perform other possible unsafe tasks and soon you understand how you react into it.
• Zestoretic may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, crunches or stand slowly, especially inside morning. Sit or lie down with the first sign associated with a of these effects.
• Check along with your doctor when you use a salt substitute or perhaps a merchandise that has potassium within it.
• Drink a lot of fluids while taking Zestoretic and get away from engaging in activities that can cause sweating. Dehydration, sweating in excess, vomiting, or diarrhea can result in a fall in hypertension. Contact your health care provider at the same time if any one these occur.
• Diabetes patients - Zestoretic may raise your blood glucose. High blood glucose might make you really feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or use a fruit-like breath odor. If these symptoms occur, tell your medical professional without delay.
• A persistent, unproductive cough may occur. Tell your doctor if the occurs. Recovery is rapid if the medicine is stopped.
• Patients taking medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may well not feel "normal." Tell your medical professional in case you develop any new symptoms.
• Zestoretic might not exactly be well in black patients. They may even be at greater likelihood of unwanted effects. Contact your doctor if the symptoms usually do not improve or if they become worse.
• Tell a medical expert or dentist that you take Zestoretic prior to deciding to receive any medical or dental care, emergency care, or surgery.
• Zestoretic might cause you to become sunburned easier. Avoid the sun, sunlamps, or tanning booths until you recognize how you respond to Zestoretic. Use a sunscreen or wear protective clothing in case you must be outside for more than a small amount of time.
• Zestoretic may obstruct certain lab tests, including parathyroid function tests. Be sure your physician and lab personnel know you are taking Zestoretic.
• Lab tests, including blood electrolytes, blood pressure, complete blood cell counts, and kidney function, could be performed as you use Zestoretic. These tests might be used to monitor your condition or pay attention to negative effects. Be sure to keep all doctor and lab appointments.
• Use Zestoretic with caution in the elderly; they could be more sensitive to its effects.
• Zestoretic ought to be used with extreme caution in kids; safety and effectiveness in children haven't been confirmed.
• Pregnancy and breast-feeding: Zestoretic could potentially cause birth defects or fetal death if you take it while you are pregnant. If you think you may be pregnant, contact your doctor right away. Zestoretic can be found in breast milk. Do not breastfeed while taking Zestoretic.